Ongoing avian influenza outbreaks in animals pose risk to humans – World Health Organization (WHO)
The current outbreaks of avian influenza (also called “bird flu”) have caused devastation in animal populations, including poultry, wild birds, and some mammals, and harmed farmers’ livelihoods and the food trade. Although largely affecting animals, these outbreaks pose ongoing risks to humans.
The Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the World Organisation for Animal Health (WOAH) are urging countries to work together across sectors to save as many animals as possible and to protect people.
Avian influenza viruses normally spread among birds, but the increasing number of H5N1 avian influenza detections among mammals—which are biologically closer to humans than birds are—raises concern that the virus might adapt to infect humans more easily. In addition, some mammals may act as mixing vessels for influenza viruses, leading to the emergence of new viruses that could be more harmful to animals and humans.
The goose/Guangdong-lineage of H5N1 avian influenza viruses first emerged in 1996 and have been causing outbreaks in birds since then. Since 2020, a variant of these viruses belonging to the H5 clade 2.3.4.4b has led to an unprecedented number of deaths in wild birds and poultry in many countries in Africa, Asia and Europe. In 2021, the virus spread to North America, and in 2022, to Central and South America.
In 2022, 67 countries in five continents reported H5N1 high pathogenicity avian influenza outbreaks in poultry and wild birds to WOAH, with more than 131 million domestic poultry lost due to death or culling in affected farms and villages. In 2023, another 14 countries reported outbreaks, mainly in the Americas, as the disease continues to spread. Several mass death events have been reported in wild birds, caused by influenza A(H5N1) clade 2.3.4.4b viruses.
Monitoring the recent surge in outbreaks among mammals
Recently, there have been increasing reports of deadly outbreaks among mammals also caused by influenza A(H5)—including influenza A(H5N1)—viruses. 10 countries across three continents have reported outbreaks in mammals to WOAH since 2022. There are likely to be more countries where outbreaks have not yet been detected or reported. Both land and sea mammals have been affected, including outbreaks in farmed mink in Spain, seals in the United States of America, and sea lions in Peru and Chile, with at least 26 species known to have been affected. H5N1 viruses have also been detected in domestic animals such as cats and dogs in several countries, with recent detections of H5N1 in cats announced by authorities in Poland.
“There is a recent paradigm change in the ecology and epidemiology of avian influenza which has heightened global concern as the disease spread to new geographical regions and caused unusual wild bird die-offs, and alarming rise in mammalian cases,” said Dr Gregorio Torres, Head of the Science Department at WOAH.
Assessing the risk to humans
Sporadic influenza A(H5N1) clade 2.3.4.4b virus detections in humans have also been reported, but remain very rare, with 8 cases reported since December 2021. Infections in humans can cause severe disease with a high mortality rate. The human cases detected thus far are mostly linked to close contact with infected birds and contaminated environments.
“With the information available so far, the virus does not appear to be able to transmit from one person to another easily, but vigilance is needed to identify any evolution in the virus that can change that,” said Dr Sylvie Briand, Director of Epidemic and Pandemic Preparedness and Prevention, WHO. “WHO is working closely with FAO and WOAH, and laboratory networks to monitor the evolution of these viruses, looking for signals of any change that could be more dangerous to humans. We encourage all countries to increase their ability to monitor these viruses and to detect any human cases. This is especially important as the virus is now affecting countries with limited prior experience in avian flu surveillance.”
Studies are underway to identify any changes in the virus that may help the virus to spread more easily among mammals, including humans.
“The epidemiology of H5N1 continues to rapidly evolve,” said Keith Sumption, Chief Veterinary Officer, FAO. “FAO brings attention to the need for vigilance and timely sharing of genetic sequences to monitor the molecular epidemiology for risk assessment and better disease control.”
Curbing the spread of avian influenza
Given the unprecedented spread of the A(H5N1) avian influenza virus among birds and mammals, and the potential risk to human health, the tripartite partners—FAO, WHO and WOAH—urge countries to take the following actions:
FAO, WHO and WOAH have been convening experts to review the situation, monitoring the rapidly evolving nature of the virus, and updating recommendations for curbing its spread, in addition to working with countries in preparedness and response, and facilitating collaboration across countries and sectors. The spread of the virus to five continents speaks to the need for global cooperation and alertness to protect animals, people and economies.
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